The present review describes information regarding drug Glipizide and work done on different types of formulation of glipizide. Glipizide is an oral rapid- and short-acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation sulfonylureas are both more potent and have shorter half-lives than the first-generation sulfonylureas.
Due to short half life various technology are used to sustain the effect of glipizide. This review includes all available information like Pharmacokinetics, Pharmacodynamic, Pharmacological action and side effects of glipizide. Review also includes different formulations for sustained the effect of glipizide. This review work may be very useful for person working with glipizide.
Key word: Glipizide, Controlled release Drug Delivery System.