Abstract 04 V1 I4

A simple, sensitive, spectrophotometric method in UV region has been developed for the determination of oxaprozin in bulk and tablet dosage form. Solution of oxaprozin in Methanol shows maximum absorbance at 282 nmin zero order spectrum method (method A), in first order derivative spectra (method B) show sharp peak at 270 nm when n=1, and in method C calculation of area under curve (AUC) for analysis of Oxaprozin in wavelength range 292-270nm. The drug followed the Beer-Lambert’s law in the concentration range of 4-32 µg/ml. Result of analysis were validated statically and were found to be satisfactory.

Keywords: Oxaprozin, Zero order, First order, Area under curve.