There is a great concern that exposure to man-made substances that mimic endogenous hormones may adversely affect mammalian reproduction. Bisphenol-A (BPA) is one of them and the most common compound used in industry for the manufacture of epoxy resins and polycarbonate plastics. Several studies reported BPA migrates from can surface coatings or plastics into food and with repeated use of such products; it has been detected in the biological samples of general population.
For these purposes, different approaches have been employed, from in vivo studies on female rodents to in vitro experimental procedures. Based on the review published, BPA exposure leads to negative health problems such as neurotoxic, immunotoxic, carcinogenic, genotoxic, metabolic problems, effects on social behavior, effect on fertility and reproductive tract, transgenerational inheritance and other problems.
Key words: Endogenous hormones, BPA, transgenerational inheritance.