Abstract 02 V2 I6

Niosomal promising drug delivery system and have successfully used in various treatment in the medical field. It shows sustained drug release and the localized or targeted drug delivery. Both hydrophilic and lipophilic drugs are incorporated into niosomes to improve its efficacy. So many factors will affect the physical characteristics of niosomal vesicle. The physicochemical characters of encapsulated drug, type and properties of non-ionic surfactant and the cholesterol content may affect the properties of niosomes. Loratadine is an antihistaminic drug used for the treatment of allergic diseases.

It belongs to BCS class II. Effect of surfactant and cholesterol on the loratadine loaded niosomesbe investigated by preparing niosomes using Lipid Film Hydration method. Niosomes were assessed for particle size was determination, morphological studies, entrapment efficiency and in-vitro drug release. The mean particle size was found to be in between 3.49-7.48µm. The niosomes prepared by using span 60 shows highest entrapment efficiency 94.9% and in-vitro drug release 92.6180 0.90.

Keywords: - Niosome; Cholesterol; Non-ionic surfactant; BCS II;