Botanical and nutritional compounds have been used for the treatment of cancer throughout history. These compounds also may be useful in the prevention of cancer. Population studies suggest that a reduced risk of cancer is associated with high consumption of vegetables and fruits. Dietary botanicals, including cruciferous vegetables such as cabbage and broccoli, Allium vegetables such as garlic, onion, green tea, Citrus fruits, soybeans, tomatoes, and berries are in preclinical or clinical trials for cancer. Indole-3-carbinol (I3C), naturally found in high concentration in cruciferous vegetables, has been shows promising activities in preventing development and growth of breast cancer.
The main aim of the study was to screen the hydro alcoholic extracts from of Brassica oleracea. f rubra and Brassica oleracea. f alb leaves, herbomineral complex and Indole-3-carbinol for their in vitro anti-oxidant and anticancer activity against OVCAR-3 cell lines. In vitro antioxidant activity of extracts was determined by DPPH Radical assay, Inhibition of lipid peroxidation. Cytotoxic effect of extracts and herbomineral was evaluated by performing Sulphorhodamine B (SRB) assay on OVCAR-3 cell lines.Extracts and herbomineral complex were found to possess significant antioxidant activity.
In SRB colorimetric assay, Indole-3-carbinol, Brassica oleracea. f rubra() and Brassica oleracea. f alba().Extract and their herbomineral complex with zinc was evaluated and compared to anticancer activity. Extract of white cabbage shows a more potent activity herbomineral complex of red cabbage and white cabbage showed anticancer activity. Herbomineral complex of white cabbage has showed more potent activity then red cabbage.The observed anticancer activity of extract and complex may be due to its antioxidant potential
>Key words: Indole-3-carbinol, breast cancer, Antioxidant, Anticancer.