Abstract 08 V1 I3

Aim/objective This study was to assess the drug prescription pattern of anti epileptic drugs in epilepsy. Methods The perspective observational study was carried out at epilepsy clinic of the government general hospital Chennai – 3, on August 2004 ­– January 2004. 485 patients were enrolled in this study, following data were collected from patients prescriptions that demographical data, types of epileptic disorder and types of anti epileptic drugs used in patients.

Results and conclusions The age wise distribution of the patients is maximum numbers of patients were in the age groups 11 -20 & 21-30. 69 % patients suffered by GTCS followed by 13 % patients were in complex partial seizure, 8 % patients were with simple partial seizure 4% patients were with Focal seizure and 4% patients were with myoclonic seizure . 51% of patients were receiving single drug therapy and 48% of patient was receiving multiple drug therapy. In GTCS 44 % of patient receiving single drug therapy followed by 33% of patient receiving two drugs, 9% of patient receiving three drugs. In single drug therapy Phenytoin prescribed to 32 % patient. Phenytoin with Carbamazepine combination was widely used in GTCS. In Focal seizure 80 % patient receiving  single drug therapy , 19 % patient receiving two drugs .

In single drug therapy Carbamazepine goes first choice to  prescribe.  In Myocolnic seizure  60 % patient receiving single drug therapy , 40% patient receiving two drugs . In single drug therapy carbamazepine was most widely prescribed 50 % patients. In two drug therapy carbamazepine with sodium valporate was most widely prescribed. In simple partial seizure 36 %  patient received single drug therapy , 48% received two drug therapy , 14 % patients received three drug therapy . In three drug therapy Phenytoin was combined with Carbamazepine and sodium valporate / sodium valporate and phenobarbitone . In complex partial seizure 49 % patient received single drug therapy, 43% two drug therapy, 7 % patient received three drug therapies.

The goal of treatment in patients with epileptic seizures is to achieve a seizure free status without adverse effect . Monotherapy was a desirable because it decreases ADR and drug interactions . But older anticonvulsant agents have hepatic enzyme inducing properties that decreases the serum level of the contaminant drug , thereby increasing the required dose of the concomitant drug . People with seizures experience psychosocial adjustments after their diagnosis. Therefore social and vocational rehabilitations may be needed.

Key words:  Pattern, Antiepileptic Drugs, Epilepsy, Phenytoin, Carbamazepine.