Abstract 10 V1 I2

In the present work fast dissolving tablets of Nebivolol hydrochloride were prepared using a combined effect of various super disintergrants consisting of sodium starch glycolate, cros carmellose sodium and crospovidone in different ratios (1:1, 1:2 & 1:3) in vice versa. Nebivolol hydrochloride is a drug choice in the treatment of hypertension. Drug compatibility with excipients was checked by FT-IR studies. The powder blends were subjected to pre-compression parameter. All the formulation was subjected to post compression parameter indicated that tablets had a good mechanical strength and resistance.

Drug content was found to be in the range 93.51% - 98.99%. Among all the formulation, formulation F9 was found to be promising and was displayed an in-vitro disintegration time of 110 sec. When compared to marketed product, the formulation F9 containing combined form of super disintegrants (1:3 mixture of cross carmellose sodium and crospovidone) emerged as the overall best formulation based on drug release characteristics with 0.1 N hydrochloric acid as dissolution medium .

Short term stability studies on promising formulation F9 indicated that were no significant changes. From this study, it can be concluded that dissolution profile, drug release rate was increased significantly with increase in ratio of superdisintegrants i.e. higher the concentration of super disintegrants greater the drug release.

Key words: Nebivolol hydrochloride, sodium starch glycolate, cross carmellose sodium and crospovidone.