The present study involves the preparation and evaluation of mucoadhesive microcapsules of Paracetamol as the model drug to enhance the residence time in the body. The microcapsules were prepared with sodium alginate and ethyl cellulose using Emulsification-Solvent Evaporation Technique. The morphology and particle size of the microcapsules were detected by optical microscopy and SEM.
The drug loading efficiency was found to be 54-75.77%.The mucoadhesion testing was done by using the freshly incised goat intestine. The swelling ability was found to be 6-8.9% and 4-7.9% in distilled water and 0.1N HCl respectively. The invitro release of drug exhibited more than 12hours duration. The microcapsules prepared were found to be free flowing.
Key Words: Mucoadhesion, Scanning Electron Microscopy microcapsules, Sodium alginate, Ethyl cellulose, Paracetamol.