Group VA-containing polyesters are formed from the interfacial polymerization of the Group VA triphenylmetal dihalides with the salt of 3,5-pyridenedicarboxylic acid. Yield and molecular weight decrease as the size of the metal atom increases. Infrared spectroscopy, IR, shows formation of the M-O linkage with the geometry about the metal atom being a combination bridged and non-bridged. MALDI MS shows the presence of metal-containing ion fragment clusters of 5 to 7 repeat polymer units.
Isotopic abundance for the antimony products is consistent with the presence of one, two, and three metal atoms in the particular ion fragment cluster. The polymers exhibit good inhibition of all of the tested cancer cell lines including two pancreatic cancer cell lines that represent about 90% of human pancreatic cancers. In comparison to other metal-containing polymers derived from 3,5-pyridenedicarboxylic acid the Group VA polymers have EC50 values similar to organotin polymers and lower than for the Group IVB metallocene polymers. Conversely, the metallocene polymers exhibit higher CI50 values.
Keywords: Group VA polymers, 3,5-pyridendicarboxylic acid, metal-containing polymers, interfacial polycondensation, pancreatic cancer, breast cancer