Abstract 07 V1 I2

Snakes are the limbless vertebrates and belong to the class of living creatures known as reptiles. More than 2,000 different types of snakes exist and nearly 400 are known to be venomous. More than 40,000 people die every year from snake bite in India. The snakes have always been a potential hazard to the farmers and farm workers.

The annual mortality rate from snake bite is more in India i.e. 46,000, out of this about 12,000 die because of snake bite. Among the most venomous snakes of South East Asia Indian common krait is less studied, so in the present study the toxicity of this snake venom was observed through different routes of inoculation like subcutaneous, intramuscular, intraperitoneal, intracerebral and intravenous route of inoculation.

Objective: The study is an attempt to see one of the many characters of venom of Indian common Krait i.e. toxicity.  It provides initial information on the mode of toxic action of the venom.

Method: Experimental Method was used. The toxicity of common krait was measured in the present study as LD50 or the lethal dose 50% test. It is used theoretically as an indication of the standard toxicity value for any chemical under observation.

Results: The common krait venom was found most toxic through intracerebral route and least toxic through subcutaneous route.

Conclusion: The greater toxicity through intracerebral route provides an indication that this venom is affecting the central nervous system and is neurotoxic in nature.

Keywords: Toxicity, Indian common krait venom, LD50, intracerebral, basis for classification.