This investigation is undertaken with an aim to develop pharmaceutically equivalent, stable, cost effective and quality improved formulation of Clopidogrel bisulphate immediate release tablets. The task of developing immediate release tablet is accomplished by using a suitable diluents and super disintegrant. Faster disintegration of the tablet administrated orally minimizes absorption time and improves its bioavailability in less time. Immediate Release tablet of Anti plate drug is formulated using direct compression using super disintegrant Cross povidone. Clopidogrel is an inhibitor of platelet activation and decreases subsequent platelet aggregation.Khushboo Ranka, Narendra Singh Solanki, Anamika Chouhan and Kamal Singh Rathore
Page No. 1-21
Concepts of Sustained Release Dosage Forms
Sustained release drug delivery systems are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum utilization of the drug, increased safety margin of potent drug, reduction of fluctuation in steady-state drug levels, reduction in healthcare costs through improved therapy and shorter treatment period.
Ayush Garg, And Indrajeet Singhvi
Page No. 22-43
Neuralgia describes a variety of rare and painful conditions in which shooting, stabbing, burning, pain, or numbness occur along the course of a nerve, usually in the head or neck. Many believe that the protective sheath of the nerve deteriorates, sending abnormal messages. Like static in a telephone line, these abnormalities disrupt the normal signal of the nerve and cause pain. Most often the damage is from a blood vessel compressing the nerve. Other causes include aging, multiple sclerosis, and nearby tumors.
Ghanshyam Sevak , B S Sonigara And Kumkum Sarangdevot
Page No. 44-61
The present investigation was aimed to evaluate antimicrobial activity of various extracts of leaves and stems of Vitex negundo Linn. by Agar Cup method. The extracts of the plant (Vitex negundo Linn.) under investigation, were separately suspended in DMSO. The activity was compared with the standard Ampicillin (antibacterial) and Fluconazole (antifungal). Petroleum Ether extracts of leaves and stems showed more significant antimicrobial activity against tested species and comparable with standard.
Shailesh Sharma, Rajesh Khathuriya, Abhishek Bhanot and Vivek Kumar Gupta
Page No. 62-73
The non-animal components of the hypromellose capsule formulation are accepted for pharmaceutical use in all major global markets. Using a proprietary manufacturing process that eliminates the addition of gelling agents, HPMC capsules expand the range of capsule applications. In recent era, vegetable capsules are new approach which might be replacing the usage of gelatin or non-vegetable capsules. Hypromellose is mainly used in manufacturing of such kind of capsule shell.
Page No. 74-82
Anti-Asthmatic And Anti-Tussive Activity Of Ethanolic Extract Of Leaves Of Nyctanthes Arbortristis Linn.
Ethno pharmacological relevance: Nyctanthes arbor-tristis L. of family Oleaceae (NATL) is has been reported for use in respiratory disorders such as asthma and bronchitis. It has been scientifically evaluated for anti-allergic and antihistaminic properties; however, potential of NATL as anti-asthmatic and anti-tussive has not been evaluated till date. Material and method: The pharmacological studies were performed using guinea pigs. Anti-asthmatic activity was evaluated using 0.1% histamine and 2% acetylcholine induced asthma, Anti-tussive activity was evaluated using citric acid induced cough model. Result: The NATL has depicted anti-asthmatic effects against histamine and acetylcholine cocktail induced asthma. When compared with control group all treatment groups viz.
Kumkum Mathur @1, A K Mathur2, R Issrani1, S R Ambani3, M Goyal1
Page No. 83-89
Safety Pharmacology: An Overview
Safety pharmacology studies defined as those studies that investigate the potential undesirable pharmacodynamics effects of a substance on physiological functions. It is the discipline that seeks to predict whether a drug (in the widest sense of the word), if administered to human (or animal) populations, is likely to be found unsafe, and its professional mandate is to prevent such an occurrence.
Ahamed Noor Mansoori1, Rupesh K. Gautam2*, K. S. Rathore3
Page No. 90-98
Formulation, Characterization And Invitro Evaluation Of Mucoadhesive Microcapsules Of Paracetamol
The present study involves the preparation and evaluation of mucoadhesive microcapsules of Paracetamol as the model drug to enhance the residence time in the body. The microcapsules were prepared with sodium alginate and ethyl cellulose using Emulsification-Solvent Evaporation Technique. The morphology and particle size of the microcapsules were detected by optical microscopy and SEM. The drug loading efficiency was found to be 54-75.77%.The mucoadhesion testing was done by using the freshly incised goat intestine.
Mishra J and Nayak S.K
Page No. 99-104
A Novel Design And Expansion Of Nano Suspension
Solvent anti solvent precipitation Method are used. In this Carbamazepine was dissolved in the solvent (ethanol) at concentrations ranging from 5 to 15 mg/ml. The Purpose of the present work is to enhance solubility of carbamazepine a class II drug by Nano suspensions technology. In this Carbamazepine was dissolved in the solvent (ethanol) at concentrations ranging from 5 to 15 mg/ml.
Priyadarshani Kamble , Ravindra Kamble, Bhawani Singh Sonigara and Kumkum Sarangdevot
Page No. 105-111