Volume 1 Issue 3 2016

1. Synthesis and Antimicrobial Evaluation of 4-pyrrolidino/ Morpholino -1-aryl / Alkylpyridinium Bromides

A series of bromides (RCH2Br) containing aryl / alkyl group readily reacted with 4-pyrrolidino / morpholinopyridine to give stable pyridinium bromide (1-30). The physical and spectral (IR, 1H & 13C NMR and MS) data for 1-30 were collected to confirm the structure (s) assigned. Invitro antibacterial and antifungal activities of 1-30 against Gram positive / Gram negative and fungal species were evaluated.

A. YASODHA*, A. SIVAKUMAR, A. PURATCHIKODY
IJAPBR, 2016; 1(3):1-11


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2. Sub-acute Toxicological Evaluation of Hydromethanolic Extract of Holarrhena Antidysenterica Stem Bark

Holarrhena antidysenterica (Linn.) Wall Family Apocynaceae is also known as connessi bark in English, kutaja in Sanskrit, kura or kurchi in Hindi. Its bark and seeds have been used in the treatment of dysentery and diarhhoea, anemia, epilepsy, stomach pain and cholera. In this study, toxicity profile of the plant extract on repeated administration was studied in male and female rats. The rats were treated with doses at three different levels (150, 450 and 1350 mg/kg) of the hydromethanolic extract of stem bark of the plant orally for 28 days. During the study period, the animals were observed for signs of morbidity and mortality along with behavioral changes, effect on body weight and food and water intake.

JOHARI SARIKA*, GANDHI TEJAL
IJAPBR, 2016; 1(3):12-23


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3. Study and Design of Eugenol Derivatives as Potent Antioxidant Using Quantum Mechanical Method

The main component of clove oil (Eugeina caryophyllata), Eugenol (4-allyl-2-methoxy phenol) is a phenolic compound. Among many natural and synthetic antioxidants compounds, mono and polyphenols have been the focus of both experimental and computational research on the mechanism of free radical scavenging. A series of eugenol derivatives have been studied for their antioxidant properties.

NEERA SHARMA*, DINESH KUMAR
IJAPBR, 2016; 1(3):24-32


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4. Identification of Bioactive Compounds of Nyctanthes Arbortristis Linn by Gc-ms

The objective of the present study is to determine possible bioactive compounds of the different extract fractions of entire plant of Nyctanthes arbortristis linn. The present research work was carried out by using GC-MS analysis, while mass spectra of the compounds found in the extract fraction was conducted by using the database of national institute of standard and technology (NIST) having more than 62000 patterns. Forty components from different extract fraction of entire plant were identified. Active principles with their retention time, area, height of peak, percentage of area of peak were obtained.

MRUNAL K. SHIRSAT*, INDRA JEET SINGHVI, KHEMCHAND GUPTA, AYUSH GARG
IJAPBR, 2016; 1(3):33-42


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5. Assessment of Polypharmacy Among the Geriatric Poulation in a Tertiory Care Hospital in Kerala; a Prospective Study

This study was performed to asses and establishes the prevalence of polypharmacy in geriatric population at Relief Hospital Malppuram, Kerala, on June 2011 to February 2012. Demographic analysis of this prospective study revealed the 508 patients, 290 (57.08%) were male and 218 (42.9%) were female maximum patients were in the age group of 55-59 (29.72%) range led to a significant increase in the number of medications. the most common diagnoses was Cardiovascular system disorders in 169 (33.26 %) patients, and Endocrine disorder ( DM Mellitus) in 132(25.98 %) patients followed by Respiratory system disorders in 75 (14.76 %) patients, The Co morbidity Disease which express, 35 patients (6.89%) of the patients suffer by DM , Hypertension with Hyperlipididimia and 33(6.50%) patients were suffer by Hyperlipididimia with Hypertension.

A.SRINIVASAN٭, DR.N.SENTHIL KUMAR , T.VENKATACHALAM, G.SEKAR, V.KISHOREKUMAR, AT.ABDULRAHMAN
IJAPBR, 2016; 1(3):43-48


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6. Evaluation of Antioxidant Effect and Anticancer Activity Against Ovarian Cancer (Ovcar-3) Cell Line of Brassica Oleracea and Herbomineral Complex

Botanical and nutritional compounds have been used for the treatment of cancer throughout history. These compounds also may be useful in the prevention of cancer. Population studies suggest that a reduced risk of cancer is associated with high consumption of vegetables and fruits. Dietary botanicals, including cruciferous vegetables such as cabbage and broccoli, Allium vegetables such as garlic, onion, green tea, Citrus fruits, soybeans, tomatoes, and berries are in preclinical or clinical trials for cancer. Indole-3-carbinol (I3C), naturally found in high concentration in cruciferous vegetables, has been shows promising activities in preventing development and growth of breast cancer. The main aim of the study was to screen the hydro alcoholic extracts from of Brassica oleracea. f rubra and Brassica oleracea. f alb leaves, herbomineral complex and Indole-3-carbinol for their in vitro anti-oxidant and anticancer activity against OVCAR-3 cell lines.

S PATIL* AND A ANSARI
IJAPBR, 2016; 1(3):49-58


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7. Comparative Study of Alkaloids in Selected Medicinal Plants of Mansehra District

Alkaloids were extracted and estimated from three medicinal plants of Mansehra. Three medicinal plants Menthaarvensis, Parthemiumhysterium and Colchinaspp were collected from different locations of Mansehra. The plant parts were dried and stored in powder form for extraction of different alkaloids. The extraction of alkaloids was done bySoxhlet method and Reflux method. It was found that maximum quantity of alkaloids was present in Colchinaspp(251mg) followed byMenthaarvensis(213mg), Parthemiumhysterium (195mg) by Soxhlet method while by Reflux method maximum alkaloids were present in Menthaarvensis(197mg) followed by Colchinaspp(109mg) , Parthemiumhysterium (67mg).

NAJEEB ULLAH*, AZHAR ABBAS*, FARHAN HAIDER
IJAPBR, 2016; 1(3):59-65


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8. Evaluation of Prscribing Pattern of Antiepileptic Drugs in Epilepsy

Aim/objective This study was to assess the drug prescription pattern of anti epileptic drugs in epilepsy. Methods The perspective observational study was carried out at epilepsy clinic of the government general hospital Chennai – 3, on August 2004 ­– January 2004. 485 patients were enrolled in this study, following data were collected from patients prescriptions that demographical data, types of epileptic disorder and types of anti epileptic drugs used in patients.

A.SRINIVASAN*, T.VENKATACHALAM, N.SENTHILKUMAR, K.C.ARULPRAKASAM, P.S. ATHMAJA KRISHNA
IJAPBR, 2016; 1(3):66-71


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9. Study of the Variations of the Different Biochemical Waste Products of Human Body Measured in K.f.t Biochemistry Tests of Kidney Function

Kidney is an important organ of the human body. It removes the waste product of the body metabolism and reabsorbs certain things which are required by the body. The function of the kidney is measured by Kidney Function Test(K.F.T).In this test other biochemical wastes of the body like creatinine,uric acid,urea,potassium,chloride and sodium are measured. Excreted creatinine levels can be correlated to the renal function as creatinine is not reabsorbed by kidney. In this study the creatinine levels of both clinically normal and critical ranges are correlated with other renal bio-chemical parameters.

DR.BHUPENDRA KR.SHARMA* AND MS.PRIYANKA MISHRA
IJAPBR, 2016; 1(3):72-76


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10. Phytochemical Screening of Stem of Cissus Quadrangularis- a Traditional Medicine

Cissus quadrangular is (Linn) belongs to a family- Vitaceae and are found in hotter parts of India, Ceylon, East Africa and Malaysia and Thailand. It is commonly known as “bone setter or Hadjod” in Ayurveda it has used as fracture healing and used as a food supplement. Phytochemical study of CQ showed high contents of triterpenoids, Flavonoids, saponins, glycosides, alkaloids, proteins, carbohydrates, amino acids, volatile oils etc.

PRIYANKA YADAV
IJAPBR, 2016; 1(3):77-80


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Review Articles

11. Role of Probiotics in Management of Ailment

Probiotic supplements transform the intestinal microbial flora and recommend assure as a sensible means of enhancing gut and immune function. The intestinal microbial flora consists of diverse bacterial species that dwell in the gastrointestinal tract. These bacteria are integral to the ontogeny and regulation of the immune system, protection of the body from infection, and maintenance of intestinal homeostasis. The interaction of the gut microbial flora with intestinal epithelial cells and immune cells exerts beneficial effects on the upper respiratory tract, skin and uro-genital tract.

KAPOOR D*, VYAS RB, LAD C, PATEL M
IJAPBR, 2016; 1(3):81-90


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