Volume 1 Issue 4 2016

Research Articles

1. Qualitative Analysis of Phytochemical Compounds in Ocimum Basilicum Grown in Qatar.

Evaluation of the chemical constituents of Ocimum bacilicum (locally known as Mashmoom) adopted to grow in the desert environment of the Gulf region is limited. Accordingly, the purpose of this study was to qualitatively evaluate the complete composition of phytochemical compounds present in this plant. Both methanolic and aqueous extracts of Ocimum basilicum grown in Qatar were prepared and tested for various phytochemical present in these extracts using qualitative tests. The analysis revealed the presences of glycosides, tannins, terpenoids, phenols, and phlobatatannins in both extracts.

AMEENA FAKHROO* AND LAKSHMAIAH SREERAMA
IJAPBR, 2016; 1(4):1-7


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2. Media Optimization Studies for Fermentative Production of Glucose Isomerase

Glucose isomerase (GI, EC 5.3.1.5) a successful commercial enzyme used to convert D-glucose to D-fructose. Here media for GI production was optimized using design of experiments (DoE) study. The yeast extract, sucrose and MgSO4.7H2O were found to be the most critical parameter for the production of GI through OVAT screening. It has been interpreted that yeast extract, an enriched nitrogen source and sucrose, a cheap carbon source were responsible for the built up of biomass MgSO4.

VIKI RAJENDRA CHOPDA, KARUNA NARSAPPA NAGULA, DNYANESHWAR VITTHAL BHAND, ANIRUDDHA BHALCHANDRA PANDIT*
IJAPBR, 2016; 1(4):8-16


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3. A Study to Determine the Variables Considered as Most Unethical by Medical Students in Goa

In order to find out from the medical students what they consider as most unethical and less unethical, I asked a sample of them to rank five variables in terms of most unethical to least unethical. The five variables were costly drugs, sponsorships, gifts, Government doctors doing private practice and overprescribing. The Thurstone Case V scaling technique was used to find out which variable was most unethical and which was least unethical. Of the five accepting gifts was considered as most unethical, because a gift can range from a simple innocent pen to an expensive car in certain cases.

PRADEEP SALGAONKAR, SILVEIRA CEDRIC THOMAS*
IJAPBR, 2016; 1(4):17-22


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4. Analytical Method Development and Validation of Oxaprozin in Pharmaceutical Formulation by Uv Visible Spectrophotometry.

A simple, sensitive, spectrophotometric method in UV region has been developed for the determination of oxaprozin in bulk and tablet dosage form. Solution of oxaprozin in Methanol shows maximum absorbance at 282 nmin zero order spectrum method (method A), in first order derivative spectra (method B) show sharp peak at 270 nm when n=1, and in method C calculation of area under curve (AUC) for analysis of Oxaprozin in wavelength range 292-270nm.

M. A. KUCHEKAR*, S.P. MAHAPARALE, G. A. PHADTARE
IJAPBR, 2016; 1(4):23-27


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5. Prospective Study on Effectiveness of H.pylori Radication Therapy and Utilization of Acid Suppressant Medications in Patients With Peptic Ulcer Disease

The study is to assess the Effectiveness of Helicobacter Pylori Eradication Therapy and Utilization of Acid Suppressant Drugs in patients with Peptic ulcer disease at Gastroenterology department of manak hospital at kerala on May 2012 to February 2013. Totally 280 patients profile is taken for the study from this 82 patients age comes below 65 years and 198 patients were above 65 years, Proton pump inhibitors has prescribed to 208 patients by Omeprazole has given to 122 patients followed by Pantoprazole to 87 patients and others PPIs for 71 patients, histamine receptor antagonist has given to 44 patients and other ASMs used to 34 patients.66% patients prescriptions has changed from PPIs to H2RAs and similarly 46% prescription has changed from H2RAs to PPIs. 74% patients prescribed ASDs for 1- 3 month duration and remaining 26% patients receiving over prescribing, ASMs has prescribed to 41% patients is for correct indications (justified) the remaining was considered as unjustified cases.

A.SRINIVASAN*, T.VENKATACHALAM, G.THOMOTHARAN, KC.ARUL RAKASHAM, FEBA SOSA KURIEN,
IJAPBR, 2016; 1(4):28-39


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6. Assessment of Efficacy of Aceclofenac Versus Tramadol in Osteoarthritis Patients

Osteoarthritis (OA) is a common, slowly progressive disorder affecting primarily the weight-bearing diarthrodial joints of the peripheral and axial skeleton. This is an open label study conducted in both in patients and out patients to assess the aceclofenac and tramadol efficacy in osteoarthritis patients whom doctor decided to start with non-selective NSAIDs. The whole work is carried out in 126 patients for a period of 11 months from November 2011 to September 2012. Eligible patients were interviewed by asking questions from the standard WOMAC questionnaire and reviewed on three weeks basis. The patients were divided in to two class accordance with the drugs they have taken. The first follow up was taken after completing 3 week therapy.

A.SRINIVASAN*, T.VENKATACHALAM, G.THAMOTHARAN, G.SEKAR, N. SENTHILKUMAR
IJAPBR, 2016; 1(4):40-46


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Review Articles

7. A Review: Quality Risk Management Methods and Their Potential Applications

ICH Q9 Quality risk management guidelines from the ICH provide an excellent high level framework for the use of risk management in pharmaceutical product development and manufacturing. This guidance was developed within the Expert Working Group (Quality) of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Quality Risk Management is a systematic process for the assessment, control, communication and review of risks to the quality of the medicinal product across the product lifecycle." (ICH Q9).

SONALI MAHAPARALE *, GAURI PHADTARE, MADHAVI KUCHEKAR, SNEHA WALASEIJAPBR,
2016; 1(4):47-66


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8.Prions-friends or Enemies

Prions are infectious neurodegenerative and fatal diseases in humans and animals. Prions are altered type of normal protein known as cellular Prion proteins (PrPc), which are found majorly on the surface of CNS cells. They play an important role in protecting cells and helping cells in responding to oxygen deficiency and metabolism. Prion accumulation in the brain leads to neuronal cell death or degeneration of neuronal tissue.

BLESSY JACOB*, LATA KHANI BISHT, DR. VINEETH CHANDY
IJAPBR, 2016; 1(4):67-71


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9. Αlpha Synuclein Misfolding and Neurodegenrative Disease

Parkinson’s disease (PD) results primarily from the 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced do death of dopaminergic neurons in the substantia nigra. paminergic neurodegeneration. Exposure of humans to Current PD medications treats symptoms; none halt or MPTP causes a syndrome that mimics the core neuroretard dopaminergic neuron degeneration. Although the etiology for sporadic Parkinson’s disease is unknown, information gleaned fromboth familial forms of the disease and animal models places misfolded _-synuclein at the forefront. The disease is currently without a cure and most therapies target themotoric symptoms relying on increasing dopamine tone. Association of alpha-synuclein with oxidized lipid metabolites can lead to mitochondrial dysfunction in turn leading to dopaminergic neuron death and thus to Parkinson’s disease. Parkinson’s disease is the second most common neurodegenerative disease, after Alzheimer’s disease, among the aging human population. Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with unknown function, to both familial and sporadic Parkinson's disease (PD).

KAPOOR D*, VYAS RB, LAD C, PATEL M
IJAPBR, 2016; 1(4):72-78


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10. Caffeine and Women’s Fertile Health

Caffeine, a plant alkaloid and CNS stimulant is generally recognized as safe drug. Caffeine is consumed daily in various forms such as coffee, tea, cola and other beverages. Some studies suggest that caffeine adversely affects the fertility, pregnancy and post natal health. Excessive pre-pregnancy caffeine consumption may delay the conception. Caffeine intake in certain quantities during pregnancy is associated with low birth weight, growth restriction, preterm delivery and fetal loss.

KAPOOR D*, VYAS RB, LAD C, PATEL M
IJAPBR, 2016; 1(4):72-78


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