Abstract 06 V1 I1

Ethno pharmacological relevance: Nyctanthes arbor-tristis L. of family Oleaceae (NATL) is has been reported for use in respiratory disorders such as asthma and bronchitis. It has been scientifically evaluated for anti-allergic and antihistaminic properties; however, potential of NATL as anti-asthmatic and anti-tussive has not been evaluated till date. Material and method: The pharmacological studies were performed using guinea pigs. Anti-asthmatic activity was evaluated using 0.1% histamine and 2% acetylcholine induced asthma, Anti-tussive activity was evaluated using citric acid induced cough model.

Result: The NATL has depicted anti-asthmatic effects against histamine and acetylcholine cocktail induced asthma. When compared with control group all treatment groups viz. atropine, mepyamine, NATL 100, 200 and 300 mg/kg were found offering statistically significant (P<0.05) increases in preconvulsive time and produced 210.4, 229.9, 170.1, 215.0 and 238.8% increase in latency in convulsion respectively. The NATL have depicted anti-tussive effects against citric acid induce coughing, it increases the latency of onset of cough and frequency of coughing. Conclusion: Based on the results of present study it can be concluded that NATL possesses anti-asthmatic potential.