A new class of heterocyclic compounds containing pyrimidine and thiazolidinone rings was screened for antidiabetic, anti-inflammatory and antioxidant activity by alpha-amylase inhibition, inhibition of protein denaturation and hydrogen peroxide radical scavenging activity respectively by using in vitro method. Compounds E1, E3, E6, E7, E11, and E12 have shown promising anti-diabetic activity. Compounds E2, E4, E6, and E10 have shown promising anti-inflammatory activity at 600 µg/ML. concentration. Compounds E1, E6, E8, E 9 and E11 have shown promising antioxidant activity at 250 µg/ml.
Keywords: Pyrimidine, Thiazolidinone antidiabetic, anti-inflammatory, antioxidant