Recently, fast dissolving films are gaining interest as an alternative of fast dissolving tablets. The films are designed to dissolve upon contact with a wet surface, such as the tongue, within a few seconds, meaning the consumer can take the product without need for additional liquid. This convenience provides both a marketing advantage and increased patient compliance. As the drug is directly absorbed into systemic circulation, degradation in gastrointestinal tract and first pass effect can be avoided. These points make this formulation most popular and acceptable among pediatric and geriatric patients and patients with fear of choking.
In order to assist these patients, several fast-dissolving drug delivery system have been The present work aimed at preparing Fast Dissolving Film (FDF) of Etophylline,with the purpose of developing a dosage form for a very quick onset of action, which is beneficial in managing severe conditions of asthma aiding in the enhancement of bioavailability, and is very convenient for administration, without the problem of swallowing and using water.The films of Etophylline were prepared by using polymers such as hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA), as either single polymer or in combination of two, by a solvent casting method. They were evaluated for physical characteristics such as uniformity of weight, thickness, folding endurance, drug content uniformity, surface pH, percentage elongation, and tensile strength, and gave satisfactory results. The formulations were subjected to disintegration, in vitro drug release tests. A marked increase in the dissolution rate was exhibited by fast-dissolving films of Etophylline, containing HPMC as a polymer. Fast dissolving films of Etophylline can be considered suitable for clinical use in the treatment of asthma where a quicker onset of action for a dosage form is desirable along with the convenience of administration.
Key word: HPMC, PVA, FDF