Recent developments in the dosage form technology resulted in the development of Fast dissolving tablets (FDTs) with improved patient compliance and convenience. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Fast Dissolving tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules.
The objective of the present study was to prepare the fast dissolving tablets of Albendazole. Albendazole is broad spectrum anthelmintic use against many helminthes. It is used for treatment of Threadworm, Hookworm, and Tapeworm. It has low bioavailability due to its first pass metabolism. In the present work, Fast dissolving tablets of Albendazole were design with a view to provide a quick onset of action and a better dissolution rate and further improving the bioavailability of the drug.
In this study, an attempt was made to fasten the drug release from the oral tablets by incorporating the super disintegrant and camphor/ammonium bicarbonate as subliming agents. The prepared fast dissolving tablets were subjected to pre-compression analysis and evaluated for hardness, weight variation, friability, wetting time, water absorption ratio and disintegration time.
From the results of in vitro drug release studies, the formulation F9 exhibited fast release profile of about 98.20% in 16 min and disintegration time 65.60 sec when compared with other formulations. For the optimized formulation F9, the initial dissolution rate was 36.5% / 2 min. Fourier transform infrared spectroscopy studies revealed that there was no possibility of interactions between drug and excipients. The present study demonstrated potential for rapid absorption, improved bioavailability, effective therapy and patient compliance.
Key Words: Fast Dissolving tablets (FDTs), Albendazole, Super Disintegrant, Subliming agent.