Abstract 03 V2 I5

Organotin polyethers are synthesized from the interfacial polymerization of dicumarol and diorganotin dihalides in near 100% yields. The products show infrared bands characteristic of the formation of the Sn-O linkage. MALDI MS shows ion fragment clusters to two units. Isotopic abundance comparisons are consistent with the present of tin atoms in the ion fragment clusters. Proton NMR is consistent with the presence of both reactants in the product and absence of the dicumarol protons. The products exhibit cell inhibition towards all of the cancer cell lines including two pancreatic cancer and breast cell lines.

Keywords: organotin polyethers, organotin polymers, MALDI MS, pancreatic cancer, cancer, dicumarol